Thus, the liver failure
in Pemt−/− mice appears to be due to a loss of membrane integrity
caused by a decrease in the PC/PE ratio of the plasma membrane.
Furthermore, manipulation of the PC/PE ratio suggested that this parameter
plays a key role in maintaining cell membrane integrity and has a role in the progression of steatosis to steatohepatitis that was
observed in Pemt−/− mice fed the CD diet for 3 days [59].