Background. Perforation peritonitis is the one of the commonest emergency encountered by surgeons. The aim of this paper is to
provide an overview of the spectrum of perforation peritonitis managed in a single unit of a tertiary care hospital in Delhi. Methods.
A retrospective study was carried out between May 2010 and June 2013 in a single unit of the department of Surgery, Lok Nayak
Hospital, Delhi. It included 400 patients of perforation peritonitis (diffuse or localized) who were studied retrospectively in terms
of cause, site of perforation, surgical treatment, complications, and mortality. Only those patients who underwent exploratory
laparotomy for management of perforation peritonitis were included. Results. The commonest cause of perforation peritonitis
included 179 cases of peptic ulcer disease (150 duodenal ulcers and 29 gastric ulcers) followed by appendicitis (74 cases), typhoid
fever (48 cases), tuberculosis (40 cases), and trauma (31). The overall mortality was 7%. Conclusions. Perforation peritonitis in India
has a different spectrum as compared to the western countries. Peptic ulcer perforation, perforating appendicitis, typhoid, and
tubercular perforations are the major causes of gastrointestinal perforations. Early surgical intervention under the cover of broad
spectrum antibiotics preceded by adequate aggressive resuscitation and correction of electrolyte imbalances is imperative for good
outcomes minimizing morbidity and mortality.