The purpose of this study was to investigate the modulating
effects of phyllanthin and hypophyllanthin on vascular tension
and the influence of endothelium. In this study, we also
determined if phyllanthin and hypophyllanthin could affect the
alteration of cytosolic Ca2+ in smooth muscle cells, independently
from the influence of endothelium. It was possible that
the endothelium-independent effects of these two compounds
involved with alteration in extracellular Ca2+ entry and
intracellular Ca2+ release in the smooth muscle.