28. Vibrio cholerae - Enterotoxin
• V.cholrae produce heat labile enterotoxin with a Moll wt.
• Ganglioside GM1 serves as a mucosal receptor for subunit B, which promotes entry of subunit A into the cell
• Activation of subunit A1 yields increased levels of intracellular cAMP and results in prolonged hyper secretion of water and electrolytes
• There is increased sodium dependent chloride secretion, and absorption of sodium and chloride is inhibited
• The genes for V.cholrae Enterotoxin are on the bacterial chromosome