Zoledronic acid 4 mg given as a 5‑min infusion had been
shown to result in an increased risk of renal toxicity, as
measured by increases in serum creatinine, which could
progress to renal failure. The incidence of renal toxicity and
renal failure had been shown to be reduced when zoledronic
acid 4 mg was given as a 15‑min infusion. Zoledronic acid
should be administered over no less than 15 min