2.2. Animals
Experimental procedures were carried out in accordance with
the Guide for the Care and Use of Laboratory Animals, and before
the animal experiments were carried out, the procedures were
approved by the Committee of Scientific Research and the Committee
of Animal Care of the West China Hospital, Sichuan University
(Chengdu, China). Twelve healthy Beagle dogs (six male and six
female) weighing 12.0ฑ2.0 kg (Certificate No. SYXK 2013-058)
were provided by the Institute of Laboratory Animals Sichuan
Academy of Medical Sciences.