The aim of the presentworkwas to study the alterations of the antioxidant defenses and the overall susceptibility
to oxidative stress of the terrestrial snail Cantareus apertus exposed to the carbamate pesticide Carbaryl at a low
environmentally realistic concentration.
The animals were exposed to Lactuca sativa soaked for 1 h in 1 μM Carbaryl. The temporal dynamics of the
responses was assessed by measurements at 3, 7 and 14 days of exposure.
C. apertus exposed to Carbaryl activates a number of enzymatic antioxidant responses, represented by the early
induction of catalase, glutathione peroxidase, glutathione reductase, followed by a delayed induction of superoxide
dismutase. Concomitantly, a derangement of the total oxyradical scavenging of the tissueswas observed, suggesting
an overall impairment of the tissue capability to neutralize ROS probably resulting from the overall
negative balance between enzymatic antioxidant defense capability and oxidative stress intensity. This negative
balance exposed the animals to the risk of oxidative stress damages including genotoxic damage. Compared to
acetylcholinesterase inhibition, the antioxidant responses developed to Carbaryl exposure at the low concentration
utilized showed a greater percentage variation in exposed organisms.
The results pointed out the high sensitivity of the antioxidant and oxidative stress related responses to Carbaryl
exposure at an environmental realistic concentration, demonstrating their usefulness in environmental monitoring
and risk assessment. The study highlights also the usefulness of the terrestrial snail C. apertus as potential
bioindicator species for assessing the risk of pesticide environmental contamination
จุดมุ่งหมายของ The aim of the presentworkwas to study the alterations of the antioxidant defenses and the overall susceptibility
เพื่อศึกษาการเปลี่ยนแปลงของการป้องกันสารต้านอนุมูลอิสระและความอ่อนแอโดยรวมความเครียดออกซิเดชันของCantareus to oxidative stress of the terrestrial snail Cantareus apertus exposed to the carbamate pesticide Carbaryl at a low
สัมผัสกับยาฆ่าแมลงคาร์บาเมคาร์บาริที่ต่ำเข้มข้นจริงกับสิ่งแวดล้อมenvironmentally realistic concentration.
สัตว์ได้สัมผัสกับ The animals were exposed to Lactuca sativa soaked for 1 h in 1 μ μM Carbaryl. The temporal dynamics of the
responses was assessed by measurements at 3, 7 and 14 days of exposure.
C. apertus exposed to Carbaryl activates a number of enzymatic antioxidant responses, represented by the early
induction of catalase, glutathione peroxidase, glutathione reductase, followed by a delayed induction of superoxide
dismutase. Concomitantly, a derangement of the total oxyradical scavenging of the tissueswas observed, suggesting
an overall impairment of the tissue capability to neutralize ROS probably resulting from the overall
negative balance between enzymatic antioxidant defense capability and oxidative stress intensity. This negative
balance exposed the animals to the risk of oxidative stress damages including genotoxic damage. Compared to
acetylcholinesterase inhibition, the antioxidant responses developed to Carbaryl exposure at the low concentration
utilized showed a greater percentage variation in exposed organisms.
The results pointed out the high sensitivity of the antioxidant and oxidative stress related responses to Carbaryl
exposure at an environmental realistic concentration, demonstrating their usefulness in environmental monitoring
and risk assessment. The study highlights also the usefulness of the terrestrial snail C. apertus as potential
bioindicator species for assessing the risk of pesticide environmental contamination
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