Type 1 diabetes generally results from an inability of the im-
mune system to recognize glutamic acid decarboxylase (GAD),
insulin, and other related protein [22]. On the other hand, Type
2 diabetes is associated with lifestyle. For therapeutic use in
Type 1 diabetes, genetically modified plants have been gener-
ated that express autoantigens of insulin-dependent diabetes
mellitus (IDDM), GAD [23] and insulin linked to the C-termi-
nus of the cholera toxin B subunit (CTB-INS) [24]. These re-
ports indicated an effective suppression of pancreatic islet
inflammation (insulitis) in the nonobese diabetic (NOD)
mouse. In this report, we describe genetically modified rice
seeds containing an GLP-1 analogue as part of the rice seed
storage protein globulin for possible application to patients
with Type 2 diabetes. The in vitro test demonstrates that these
genetically modified rice seeds could stimulate insulin secretion
from a mouse pancreatic beta-cell line