hyaluronidase
[hī′əlyoo͡ron′ədās]
an enzyme that hydrolyzes hyaluronic acid, a component of the extracellular matrix.
indications It is prescribed to increase the absorption and dispersion of parenteral drugs that have extravasated (e.g., vesicant chemotherapeutics), for hypodermoclysis, and for improvement of resorption of radiopaque agents.
contraindications Acute inflammation, infection, or known hypersensitivity to this drug prohibits its use.
adverse effect The most serious adverse effect is hypersensitivity.