The main aim of this paper is to identify and describe empirically supported universal, selected, and indicated prevention interventions (Mrazek & Haggerty, 1994) for substance abuse, violence, and delinquency in adolescence by addressing major risk behaviors in early childhood (ages 0-8 years). We have combined these three serious adolescent problems because the risk factors for each are similar and they are often closely interrelated. Universal preventive interventions aim at all children in a geographic area without selective criteria. Selective preventive interventions aim at children at risk because of socio familial and environmental factors. Indicate preventive interventions aim at children with personal factors such as diagnosed ODD or CD. We begin this review by briefly highlighting some of the indicated parent and child focused preventive in-terventions that have targeted a reduction in conduct problems in young children because of the centrality of this risk factor and because derivatives of these programs have often been used to develop universal and selective programs. A few selective parent programs are also included in this summary. Next we highlight universal classroom-focused prevention interventions that target the child’s peer relationships at school and teacher classroom management skills. Finally we review multifocused interventions that combine universal interventions with more intensive selective and indicated interventions for high-risk children. We believe that applied settings would be best served if their prevention programs reflected a continuum of service from universal to selected to indicated prevention as well as intervention for children with identifiable problems.We conclude by outlining key features of effective programs.