The characteristic pain associated with dry socket has been attributed to the formation of kinins in the alveolus. The kinins activate the primary afferent nerve terminations, which could have been sensitized previously by other inflammatory mediators and other allogeneic substances, which in concentrations of 1 ng/mL cause intense pain.1,21 Plasmin is also involved in the conversion of kallikrein into kinins in the osseous alveolar marrow. Thus, the presence of plasmin might be a possible explanation for both significant aspects of dry socket (ie, neuralgic pain and clot disintegration).