Neuromyelitis optica (NMO) is an inflammatory disease
of the central nervous system (CNS) characterized by
severe optic neuritis (ON) and transverse myelitis (TM)1
.
Aquaporin-4 (AQP-4) antibody, also known as NMO-IgG, an
autoantibody exclusively detected in the sera of NMO, is directed
against AQP-4, a water channel richly expressed on
foot processes of astrocytes in the CNS2,3.