Three trials in normotensives (n=2326), five in untreated hypertensives (n=387) and three in treated hypertensives (n=801) were
included, with follow up from six months to seven years. The large, high quality (and thereforemost informative) studies used intensive
behavioural interventions.
Deaths and cardiovascular events were inconsistently defined and reported; only 17 deaths equally distributed between intervention
and control groups occurred. Systolic and diastolic blood pressures were reduced at 13 to 60 months in those given low sodium advice
as compared with controls (systolic by 1.1 mm Hg, 95% CI 1.8 to 0.4, diastolic by 0.6 mm hg, 95% CI 1.5 to -0.3), as was urinary 24
hour sodium excretion (by 35.5 mmol/ 24 hours, 95% CI 47.2 to 23.9). Degree of reduction in sodium intake and change in blood
pressure were not related. People on anti-hypertensive medications were able to stop their medication more often on a reduced sodium
diet as compared with controls, while maintaining similar blood pressure control.
Three trials in normotensives (n=2326), five in untreated hypertensives (n=387) and three in treated hypertensives (n=801) wereincluded, with follow up from six months to seven years. The large, high quality (and thereforemost informative) studies used intensivebehavioural interventions.Deaths and cardiovascular events were inconsistently defined and reported; only 17 deaths equally distributed between interventionand control groups occurred. Systolic and diastolic blood pressures were reduced at 13 to 60 months in those given low sodium adviceas compared with controls (systolic by 1.1 mm Hg, 95% CI 1.8 to 0.4, diastolic by 0.6 mm hg, 95% CI 1.5 to -0.3), as was urinary 24hour sodium excretion (by 35.5 mmol/ 24 hours, 95% CI 47.2 to 23.9). Degree of reduction in sodium intake and change in bloodpressure were not related. People on anti-hypertensive medications were able to stop their medication more often on a reduced sodiumdiet as compared with controls, while maintaining similar blood pressure control.
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