Besides all the above mentioned information, endophytic and/or plant growth-promoting bacteria can be used in combination with other microorganisms in the control of pest insects in agriculture. In this context, Broderick et al. (2000) identified an increase of 35% in the mortality of the lepidopterous Lymantria dispar (L.) when using B. thuringiensis and zwittermycin A of Bacillus cereus, which is responsible for the synergetic effect of the microorganisms. Results from Wraight and Ramos (2005) also show synergism of 35.2, 33.8, and 21.1% when commercial products based on B. thuringiensis and on the fungus Beauveria bassiana were simultaneously used in Leptinotarsa decemlineata. These authors reveal that the interaction may have resulted from the intoxication caused by entomopathogen, inhibiting insect feeding, thus causing stress, and physiological effects, which facilitated fungus penetration in the insect. Similar effects were also observed by Ma et al. (2008), when the Cry 1Ac protein of B. thuringiensis was used with B. bassiana. These authors observed deleterious effects in the mortality of larvae of Ostrinia furnacalis (Lepidoptera: Crambidae), besides the decrease in the formation of pupae and emergence of the adult insects.