New insights in antibiotic resistance of Lactobacillus species from
fermented foods
Bacteria belonging to the genus Lactobacillus are used as starter cultures or that develop naturally as fermenting microbiota
in the production of various foods. On the detrimental side, lactobacilli may act as reservoir of antibiotic resistance
genes, which can spread to commensal bacteria in humans or animals, or to food-associated pathogens. In
the last decade, advances in molecular biology and in genome sequencing have provided more information on antibiotic
resistances in foodborne bacteria. The aim of this review was to consider and provide an up-to-date status on
phenotypic and genotypic antibiotic resistance profiles in Lactobacillus species from fermented foods and also to
highlight new information on the distribution of glycopeptide and chloramphenicol resistance genes in Lactobacillus
genomes. In silico screening of vanZ (glycopeptide resistance) and cat (chloramphenicol resistance)-
like sequences in Lactobacillus species isolated from fermented foods revealed for the first time the occurrence
of vanZ and cat genes in Lactobacillus species being highly conserved genes in the chromosome of
each species, presumably non-transferable. Further studies involving genome sequences of Lactobacillus
isolated from fermented foods, especially those relying on spontaneous fermentation, is crucial to increase
knowledge on the potential presence and spread of antibiotic resistance genes via the food route.