Statistical methods
Cox Regression analysis7 was used to calculate the multivariable adjusted hazard ratios in different levels of chocolate intake. In order to account for changes over time in the predictor, chocolate consumption, the chocolate consumption values at exam 1 were updated at exam 3 with available chocolate consumption values. A time-dependent covariates analysis8 was used to achieve the updating. A sensitivity analyses was conducted using only the actual chocolate intake at exam 1 as predictor – without updating at exam 3.