The FAME trial follows the specifications of the revised CONSORT criteria.8 This trial was a single-center study conducted at the Walter Reed Army Medical Center, a university-affiliated, suburban, tertiary care US military medical center. Eligible patients were recruited from the outpatient general medicine service and the Armed Forces Retirement Home, an affiliated retirement home of approximately 900 independently living military health care beneficiaries located in Washington, DC, and were elderly men and women (≥65 years) taking 4 or more chronic medications daily, a population selected as being at increased risk for medication nonadherence. Patients were excluded if they did not live independently (assisted living or nursing home residents were excluded) or in the presence of any serious medical condition for which 1-year survival was expected to be unlikely.