For example, if you look at exercise performance, it seems that caffeine can be somewhat beneficial, but caffeinated coffee is not. Or if you look at blood pressure and compare the effects of caffeinated coffee to the effects of caffeine, you’ll find that caffeinated coffee causes blood pressure increases that are substantially weaker than what one would expect for the amount of caffeine it contains. The same is true for the relationship between coffee, caffeine, and blood glucose after a meal. It’s possible that there are compounds in coffee that may counteract the effect of caffeine, but more research needs to be done.