African Rock Pythons are pretty easy to care for, in much the same way as Burmese pythons these guys are forgiving in their environment (more so than Burmese in fact) as the Floridian government will testify due to a theoretical scenario they prepared for in case of an invasion of these snakes as well as the already native Burmese.
The care should be provided to the highest possible level regardless of their hardiness. As for care for them the biggest issue many people have is that many rock pythons are notoriously defensive/aggresive. This is particularly true of wild caughts (especially the adults) however there is no reason a baby captive bred animal would have a temperament any worse than a Burmese Python. I have personally dealt with a 15 foot African Rock Python (p. natelensis) that was dog tame, the only issue i had with her was trying to stop her wandering off, she showed 0 signs of aggresion despite a fairly busy environment at that point and moved very slowly with calm deliberate motions. That said i've seen some specimens that have attempted to strike through glass, a rock python is what you make it.