Apart from these negative effects, in humans life-long energy restriction is not very feasible. However, there are substances that -in part- mimic the effects of energy restriction without food intake having to be reduced. Some of these compounds such as resveratrol, lipoic acid and spermidine are consumed as part of our diet. Dietary supplementation of resveratrol, of which considerable amounts are found in red wine, increased the lifespan of flies, yeast and mice on a high fat diet. In cell culture experiments, resveratrol affected molecular targets similar to energy restriction. Because of these promising findings resveratrol has attracted considerable attention. However, in other longevity studies with flies and mice, resveratrol did not affect lifespan and there is a lack of long-term studies in humans.