On the other hand, NO can freely interact with oxygen metabolites to yield nitrosating species, and the formation of nitrosamines may be important in the development of colorectal cancer in ulcerative colitis. High levels of nitrosamines have been demonstrated in rectal dialysates of patients with active inflammatory bowel disease [12]. Therefore, the obtained results warrant further research for the clinical application of CLG as chemopreventive agents for advanced ulcerative colitis patients.