Distribution of susceptibility of organisms
MICs must be determined on at least 500 isolates (and at least
300 anaerobes in addition if relevant, each species in su¤cient
numbers to establish norms, with a note on relative prevalence
among clinical isolates), which must include examples of
clinically relevant species appropriate to the class of com-
pound and its proposed clinical use.They must include isolates
showing important resistance mechanisms. For example,
methicillin-resistant Stapylococcus aureus (MRSA) and coagu-
lase-negative staphylococci should be included for the evalua-
tion of antistaphylococcal agents.