In the latest reports, preparative HPLC (YMC-PAC C18) or macroporous DM 130 resin column
chromatography were shown as a method for large scale preparations of cordycepin (10,11). However, even in these large scale
methods, further steps such as butanol partition chromatography,
silica gel column chromatography and recrystallization were
necessary to get the final purified product.