is not suitable for the growth of anaerobic bacteria,
especially Propionibacterium acnes.5 Exposure of
pilosebaceous keratinocyte cells to surface protein of
Propionibacterium acnes induces formation of free
radicals superoxide O2
leading to lipid peroxidation of
sebum. Neutrophils kill propionibacterium by producing
hydrogen peroxide (H2O2) resulted in inflammation and
further tissue damage.6