(A and B) Knockin (KI) schemes (A) azot{KO; Gal4} and (B) azot{KO;hid}.
(C–F) Wings from 10- to 13-day-old flies and quantification of developmental aberrations of the following five genotypes: (C) azot+/+, (C and D) azot{KO; Gal4}/azot
{KO; Gal4}, (C and E) azot{KO;hid}/azot{KO;hid}, (C and F) azot{KO; Gal4}/azot ;UASsickle, and (C) azot{KO; Gal4}/azot+ ;UAShid.
(G–J) Wings from 10- to 13-day-old flies and quantification of developmental aberrations after UV irradiation of the same five genotypes. Irradiation dose of 2 3
10 2 J administered during pupal stage 0.
(K and L) Comparative lifespan studies of genotypes azot{KO;hid}/azot{KO;hid} and azot/ at 29 C.
(L) Median and maximum survival of genotypes azot{KO;hid}/azot{KO;hid} and azot/.
(M and N) Lifespan studies at 25 C of the following four genotypes: (1) azot+/+, (2) azot/, (3) azot+/+; azot+, and (4) azot{KO;hid}/azot{KO;hid}. (N) Median and
maximum survival of the four genotypes.
(O) Scheme showing that specifically killing Azot-expressing cells with the general proapoptotic factor Hid is sufficient to prevent morphological malformations
and rescue azot mutant phenotypes.
Data are represented as mean ± SEM.