The effects of tetrodotoxin, have been tested experimentally
on a large variety of animal species such as crap, rat, Frog,
Rabbit, Dog and Cat (These effects involve primarily the
peripheral neuromuscular system, which is paralyzed to
different extents because of interference with generation and
conduction of electrical impulses (Russell and Dart, 1991).
Tetrodotoxin is a highly potent emetic agent (Atwell and
Stutchbury, 1978; Mohamed, 2003). Therefore the objective
of this study is to explore in the presence of antifouling activity
the crude extracts of two Red Sea puffer fish species,
Lagocephalus sceleratus and Amblyrhynchotes hypselogenion.