Epithelial tissues provide vital physical and permeability
barriers to vertebrates [1]. The outermost layers of the epidermis,
the stratum corneum, provide a permeability barrier that prevents
desiccation and thereby permits life on dry land [2]. The stratum
corneum lipid is an integral part of cell envelop which is consist of a
covalently bound layer to surface protein of cell membrane, and
has its essential function as structural elements of plasma