and disease.
Selection of epitope escape mutants in mice immunized
against rLm-gp33. In determining the titers of virus from infected
mice, we noticed that, under the fluorescent microscope,
the majority of viral plaques obtained from the CNS of
rLm-gp33 immunized mice were no longer fluorescent, suggesting
that viruses no longer expressed EGFP activity. However,
most of the plaques derived from the brains of nonimmunized
mice were fluorescent. We reasoned that, in mice
immunized with rLm-gp33,