we have shown that exposure to PPI is associated with increased risk of development of CKD, pro- gression of kidney disease, and risk of ESRD. The results also suggest a graded relationship between duration of exposure and risk of renal outcomes. The results were consistent in multiple sensitivity analyses, including an assessment of risk in a 1:1 propensity score-matched and balanced cohort of H2 blocker and PPI users where risk of renal outcomes was sig- nificantly elevated in patients treated with PPI compared with those treated with H2 blockers, and a 1:1 propensity
การศึกษาครั้งนี้ยกระดับความพร้อมของฐานข้อมูล ในเครือข่ายแบบบูรณาการระบบสุขภาพ ความสัมพันธ์ระหว่างPPI exposure และlong-term renal outcomes H2 blockersและ PPI—2 classes of drugs