An empirically grounded, human ecological model of spirit at work specifying antecedent conditions and outcomes of spirit at work is presented. Spirit at work is a distinct state characterized by profound feelings of wellbeing, a belief that one is engaged in meaningful work, a connection to others and common purpose, a connection to something larger than self, and it has a transcendent nature. Four distinct paths to spirit at work are identified: always there, coming together, transformative event, and contextually sensitive. These paths are affected by individual factors (personality characteristics and personal actions) and contextual factors (organizational characteristics and transformative life events) that contribute to the experience of spirit at work. This model posits that personality, personal actions, and organizational characteristics are interconnected and operate to foster or impede an individual’s spirit at work. Spirit at work appears to counteract disenchantment and disengagement at work and results in positive outcomes for employees, consumers, and organizations.