Melioidosis may have a wide range of clinical manifestations, and severity varies from an acute fulminant septic illness to a chronic infection. Shown are the routes of infection (blue boxes: percutaneous inoculation, inhalation, and ingestion), the natural history of infection (red boxes: asymptomatic infection, bacteremia, or reactivation of latent focus), and the diverse disease manifestations (white text). Panel A shows cutaneous melioidosis in a healthy host. Panel B shows lung abscesses on the chest radiograph of a patient with acute melioidosis pneumonia, and Panel C shows the corresponding computed tomographic (CT) scan. Panel D shows the skin manifestations in a fatal case of disseminated melioidosis. Panel E shows splenic abscesses on an abdominal CT scan. Panel F shows aspirated pus in a patient with prostatic and periprostatic abscesses, and Panel G shows the abscesses on a CT scan from the patient.