Abstract
Objective: Summarize data on metabolic syndrome (MS) in bipolar disorder (BD). Methods: A
systematic review of the literature was conducted using the Medline, Embase and PsycInfo
databases, using the keywords “metabolic syndrome”, “insulin resistance” and “metabolic X
syndrome” and cross-referencing them with “bipolar disorder” or “mania”. The following types of
publications were candidates for review: (i) clinical trials, (ii) studies involving patients diagnosed
with bipolar disorder or (iii) data about metabolic syndrome. A 5-point quality scale was used to
assess the methodological weight of the studies. Results: Thirty-nine articles were selected. None
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higher in BD individuals when compared to a control group. The analysis of MS subcomponents
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rates of hypertriglyceridemia than healthy controls. When compared to the general population,
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patients with BD compared to the general population. Conclusions: The overall results point to
the presence of an association between BD and MS, as well as between their subcomponents.