Among other azoles, in vitro resistance to itraconazole has
been noted, occurring at rates of from 1.5% of C. parapsilosis
isolates (10) to 4% (202), and voriconazole has lower MIC50
(0.03 g/ml) and MIC90 (0.03 to 0.12 g/ml) values than
amphotericin B and older azoles against C. parapsilosis (88,
166, 168, 177, 202, 218). In vitro resistance to voriconazole is
rare, with early reports showing 100%