In this study, we successfully encapsulated approximately 65 wt.% ofMCX in the mesoporous silica by sol–gel polymerizationmethod. The SPF value of the MCX-MS-containing sunscreen emulsion cream, MCXMS- E,was about 57% higher than that of theMCX-containing sunscreen emulsion cream, MCX-E, revealing that MCX-MS-E had much higher UV protection than MCX-E for the skin. The average diameter of emulsion droplets in MCX-MS-E could prevent the possibility of penetration through the human skin, suppressing damage to the underlying tissue.