Migraine is a chronic, multifactorial, and debilitating
neurological disorder characterized by recurrent
moderate to severe attacks of headache and
autonomic dysfunction.1 It is commonly accompanied
by several symptoms such as nausea, vomiting, phonophobia,
photophobia, and aggravation by exertion.2
According to previous population estimates, the
current global prevalence of headache and migraine
are 47% and 10%, respectively.3
Migraine imposes considerable social and economic
burdens on individual headache sufferers and
society.4The severity and extent of symptoms result in
considerably impaired social function, increased utilization
of medical services, and reduced healthrelated
quality of life.5,6
Migraine has historically been an underestimated
and undertreated disorder.3 Furthermore, approximately
half of migraine patients discontinue looking
for treatment for their headaches, partly due to dissatisfaction
with therapy. Indeed, public surveys
revealed that headache sufferers are among the most
dissatisfied patients.7 Therefore, efficient management
should include establishing logical expectations,
patient assurance, and appropriate medical treatment
and instruction.8 Moreover, successful treatment of
migraine attacks could benefit migraineurs by reducing
their disability and the need for health care
resources, and improving economic productivity.9,10
Migraine treatment is commonly divided into behavioral
therapies, acute care, and daily preventive
medication.There is a multitude of different pharmacological
options currently prescribed for acute care
of migraine.11