Preemptive dosing to time the peak pharmacodynamic
effect of IV acetaminophen to optimize analgesic effectiveness
has been studied clinically. For example, in a
study of patients undergoing total abdominal hysterectomy,
IV acetaminophen 1 g administered 30 minutes
prior to surgical incision (prior to induction) resulted in a
greater reduction in total morphine consumption compared
with administering the same dose at the end of
surgery just prior to skin closure (reference 2 in Table 1).