Introduction: This study’s objective was to systematically
review the literature to assess analgesic outcomes of intravenous
(IV) acetaminophen for acute postoperative pain in
adults.
Methods: We searched Medline and the Cochrane library
article had 4 arms. As a result, 22 study comparisons were
analyzed: IV acetaminophen to an active comparator (n = 8
studies) and IV acetaminophen to placebo (n = 14 studies).
The RCTs were of high methodological quality with Jadad
median score = 5. In 7 of 8 active comparator studies (IV
parecoxib [n = 3 studies], IV metamizol [n = 4], oral ibuprofen
[n = 1]), IV acetaminophen had similar analgesic outcomes as
the active comparator. Twelve of the 14 placebo studies
found that IV acetaminophen patients had improved analgesia.
Ten of those 14 studies reported less opioid consumption,
a lower percentage of patients rescuing, or a longer
time to first rescue with IV acetaminophen. Formal metaanalysis
pooling was not performed because the studies had
different primary end points, and the IV acetaminophen
dosing regimens varied in dose, and duration and timing.
Introduction: This study’s objective was to systematicallyreview the literature to assess analgesic outcomes of intravenous(IV) acetaminophen for acute postoperative pain inadults.Methods: We searched Medline and the Cochrane libraryarticle had 4 arms. As a result, 22 study comparisons wereanalyzed: IV acetaminophen to an active comparator (n = 8studies) and IV acetaminophen to placebo (n = 14 studies).The RCTs were of high methodological quality with Jadadmedian score = 5. In 7 of 8 active comparator studies (IVparecoxib [n = 3 studies], IV metamizol [n = 4], oral ibuprofen[n = 1]), IV acetaminophen had similar analgesic outcomes asthe active comparator. Twelve of the 14 placebo studiesfound that IV acetaminophen patients had improved analgesia.Ten of those 14 studies reported less opioid consumption,a lower percentage of patients rescuing, or a longertime to first rescue with IV acetaminophen. Formal metaanalysispooling was not performed because the studies haddifferent primary end points, and the IV acetaminophendosing regimens varied in dose, and duration and timing.
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