To consistently and efficiently assure quality standards in Higher Education (HE), Higher Education Institutions (HEIs) have put in place internal mechanisms and policies. Quality Assurance Agencies have also been set up by many countries to coordinate the proper development of HEIs. This study sought to examine the quality assurance practices of Koforidua Polytechnic (KP).The study was a descriptive qualitative research. Using the student life cycle framework the author followed students from admission stage through being taught and assessed and to graduation, looking at the quality checks at each stage. The findings suggest that KP has taken steps to assure quality in its operations. Despite these efforts, KP has not been successful in establishing a quality culture and challenges remain. Among others the author recommends that the quality assurance agencies should support Higher Education Institutions (HEIs) including KP to develop internal quality culture.