Fermentation by Lactobacillus and Pediococcus strains led to higher SOD enzyme activity than that of the Bacillus strains. Jeon et al [4] reported that the SOD enzyme activity was greatly increased when ginseng fruit extract was fermented with lactic acid bacteria; this was similar to our results with fermented ginseng seed, which showed that fermentation treatment effectively inhibited superoxide (O2).