Many variation of grip is possible with lat pulldown machine. Changing your hand position makes difference to muscle activation during the lat pulldown. Let’s focus on wide-grip lat pulldown this time. I normally do Wide Grip Lat Pulldown after pull ups and One Arm Dumbbell Row Loading. In Wide Grip Lat Pulldown exercise, main muscle worked is lats (latissimus dorsi). Other muscles such as biceps and middle back are involved too. Therefore, Wide Grip Lat Pulldown is considered as a compound exercise.