studies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica,known for exceptional longevity,had longer telomere length than those in other parts of the country. After controlling for agg,age squared,rurality,rain season and gender,
the mean leukocyte telomere length in Nicoya was substantially longer (81 base pairs,<0.05)than in other areas of Costa Rica,providing evidence of a biological pathway to which this notable longevity may be related. This relationship remains unchanged (79 base pairs,p<0.05) after statistically controlling for nineteen
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