In this paper, we target specifically the detection of milk and fish freshness and spoilage by SAW sensor array based electronic nose. The motivation is to find an efficient method for selection of an optimal set of polymers. Learning from our analyses in the past [35,60–62] we present here a much simpler method based only on the data mining by fuzzy c-means clustering. Section 3 describes the basic information needed for the selection analysis. These are: the set of volatile organic markers (odorants) for the freshness and spoilage indication, the set of prospective polymers, and the solvation data for the target odorants, interferents and listed polymers. Section 4 presents a method for polymer selection based on
fuzzy c-means (FCM) clustering analysis of the odorants-polymers solvation data. Section 5 presents the validation of the proposed selection method by simulation of SAW sensor array responses and their analysis for freshness and spoilage markers detection and concentration estimation. For this purpose the section includes a brief description of the SAW sensor response model and the radial basis function (RBF) neural network. The paper sums up with some discussion in Section 6 and conclusion in Section 7.