Acrylamide is very polar molecule with poor retention
(k < 2.0) in conventional LC reversed phase sorbents. Therefore,
LC-based methods with UV detection seem to be not
suffice for the analysis of acrylamide in processed foods at
low levels due to lack of selectivity. Since an additional degree
of analyte certainty is required to confirm the presence
of acrylamide in the complex food matrix, MS became the
choice of detection step coupled to LC. However, analytical
responses for compounds other than acrylamide were found
to be present in the MS chromatograms (m/z 72 > 55) of certain
type of food samples such as potato chips and coffee.
Therefore, it was noted that more effort should be placed on
efficient cleanup to avoid interferences for an accurate quantification
despite the use of tandem MS [20–24].