Smoothies are an excellent way to intake nutrients and bioactive compounds from both the fruits and the milk or soymilk with which they are made. High pressure processing (HPP) an thermal pasteurization (TP). Untreated, pasteurized (80 C/3 min) and HPP (450-650 MPa for 3 min at 20 C) milk- and soy-smoothies were compared. Milk- and soy-smoothies showed a total reduction in microorganisms after pasteurization and HPP at the pressure conditions applied. HPP maintained microbial stability until the end of the storage period (45 days at 4 C).