Other inflammatory cells were also significantly up-regulated when asthma was induced. WG or RG
administration effectively suppressed eosinophil infiltration into
lung bronchioles. Fig. 7 shows the marked infiltrations of in-
flammatory cells, including eosinophils, neutrophils, and lymphocytes,
observed in connective tissues not only around large
vessels and airways but also around small vessels and airways in
the control group. Although alveolar spaces were washed once
with PBS to obtain BALF, many infiltrated inflammatory cells
remained. However, in the WG and RG groups, inflammatory cell
infiltrations were much reduced as compared with the control
group. In addition, mucosal thickening was frequently observed
in the control group (Fig. 7B), but in the WG and RG groups,
mucosal thickening was moderately reduced, and RG seemed to
be more effective than WG.
AHR is a particular feature of asthma and leads to recurrent
episodes of shortness of breath, wheezing, and coughing [22]. In
the present study, we observed AHR changes by methacholine
challenge testing. WG and RG inhibited AHR as evidence by reductions
in Penh values to levels similar to those observed in the
naïve group
Other inflammatory cells were also significantly up-regulated when asthma was induced. WG or RG
administration effectively suppressed eosinophil infiltration into
lung bronchioles. Fig. 7 shows the marked infiltrations of in-
flammatory cells, including eosinophils, neutrophils, and lymphocytes,
observed in connective tissues not only around large
vessels and airways but also around small vessels and airways in
the control group. Although alveolar spaces were washed once
with PBS to obtain BALF, many infiltrated inflammatory cells
remained. However, in the WG and RG groups, inflammatory cell
infiltrations were much reduced as compared with the control
group. In addition, mucosal thickening was frequently observed
in the control group (Fig. 7B), but in the WG and RG groups,
mucosal thickening was moderately reduced, and RG seemed to
be more effective than WG.
AHR is a particular feature of asthma and leads to recurrent
episodes of shortness of breath, wheezing, and coughing [22]. In
the present study, we observed AHR changes by methacholine
challenge testing. WG and RG inhibited AHR as evidence by reductions
in Penh values to levels similar to those observed in the
naïve group
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