Rotavirus severe infection decreased
pp70S6K, pMAPK and pMAPK levels and
increased prostaglandin E2 and nitric oxide
toxicity to impede normal development of
villi enterocytes of the small intestine and
the consequent change in structure and
function of the epithelium. These changes
are likely to lead malabsorption and abnormal
motility of the gastrointestine during
rotavirus infection.