Proteomicsisinherentlyasystemsscien

Proteomicsisinherentlyasystemssciencethatstudiesnotonlymeasuredproteinandtheir
expressionsinacell,butalsotheinterplayofproteins,proteincomplexes,signalingpathways,and
networkmodules.ThereisarapidaccumulationofProteomicsdatainrecentyears.However,
Proteomicsdataarehighlyvariable,withresultssensitivetodatapreparationmethods,sample
condition,instrumenttypes,andanalyticalmethods.ToaddressthechallengeinProteomicsdata
analysis,wereviewcurrenttoolsbeingdevelopedtoincorporatebiologicalfunctionandnetwork
topologicalinformation.Wecategorizethesetoolsintofourtypes:toolswithbasicfunctional
informationandlittletopologicalfeatures(e.g.,GOcategoryanalysis),toolswithrichfunctional
informationandlittletopologicalfeatures(e.g.,GSEA),toolswithbasicfunctionalinformationandrich
topologicalfeatures(e.g.,Cytoscape),andtoolswithrichfunctionalinformationandrichtopological
features(e.g.,PathwayExpress).We firstreviewthepotentialapplicationofthesetoolstoProteomics;
thenwereviewtoolsthatcanachieveautomatedlearningofpathwaymodulesandfeatures,andtools
thathelpperformintegratednetworkvisualanalytics.

ผลลัพธ์ (ไทย) 1:

Proteomicsisinherentlyasystemssciencethatstudiesnotonlymeasuredproteinandtheirexpressionsinacell, butalsotheinterplayofproteins, proteincomplexes, signalingpathways และnetworkmodulesThereisarapidaccumulationofProteomicsdatainrecentyears.HoweverProteomicsdataarehighlyvariable, withresultssensitivetodatapreparationmethods ตัวอย่างเงื่อนไข instrumenttypes, andanalyticalmethodsToaddressthechallengeinProteomicsdataวิเคราะห์ wereviewcurrenttoolsbeingdevelopedtoincorporatebiologicalfunctionandnetworktopologicalinformationWecategorizethesetoolsintofourtypes:toolswithbasicfunctionalinformationandlittletopologicalfeatures (e.g.,GOcategoryanalysis), toolswithrichfunctionalinformationandlittletopologicalfeatures (e.g.,GSEA), toolswithbasicfunctionalinformationandrichtopologicalfeatures (e.g.,Cytoscape), andtoolswithrichfunctionalinformationandrichtopologicalfeatures(e.g.,PathwayExpress)เรา firstreviewthepotentialapplicationofthesetoolstoProteomicsthenwereviewtoolsthatcanachieveautomatedlearningofpathwaymodulesandfeatures, andtoolsthathelpperformintegratednetworkvisualanalytics

ผลลัพธ์ (ไทย) 3:

proteomicsisinherentlyasystemssciencethatstudiesnotonlymeasuredproteinandtheir
expressionsinacell butalsotheinterplayofproteins proteincomplexes signalingpathways , , , ,
networkmodules . thereisarapidaccumulationofproteomicsdatainrecentyears อย่างไรก็ตาม proteomicsdataarehighlyvariable withresultssensitivetodatapreparationmethods ตัวอย่าง

, เงื่อนไข instrumenttypes andanalyticalmethods , .การวิเคราะห์ toaddressthechallengeinproteomicsdata

wereviewcurrenttoolsbeingdevelopedtoincorporatebiologicalfunctionandnetwork topologicalinformation . wecategorizethesetoolsintofourtypes : toolswithbasicfunctional
informationandlittletopologicalfeatures ( เช่น gocategoryanalysis ) toolswithrichfunctional
informationandlittletopologicalfeatures ( เช่น gsea toolswithbasicfunctionalinformationandrich
)topologicalfeatures ( เช่น cytoscape ) คุณสมบัติ andtoolswithrichfunctionalinformationandrichtopological
( เช่น pathwayexpress ) เรา firstreviewthepotentialapplicationofthesetoolstoproteomics thenwereviewtoolsthatcanachieveautomatedlearningofpathwaymodulesandfeatures andtools ;
,
thathelpperformintegratednetworkvisualanalytics .