The histologic liver lesions in chicks in this study were dose related and similar to those in horses and rats given fumonisin. Rickets has been seen in poultry consuming rations with Fusarium and Fusarium moniliforme, but the causative toxin and the pathologic mechanism of its induction have not been determined.
In the present trial, diarrhea in fumonisintreated chicks may have led to intestinal malabsorption or maldigestion of vitamin D, calcium or phosphorus,resulting in secondary rickets. No previous reports had associated diarrhea with fumonisin toxicity,
therefore no intestinal tissues were collected for histologic evaluation. Thymic cortical atrophy is frequently seen in broiler chicks undergoing disease stress.
No immunologic assessment of the impact of this thymic lesion was attempted in this pilot study, but Fusarium equiseti2 and Fusarium moniliforme suppress humoral immunity in chickens. Fumonisin B1 also induces morphologic and functional alterations in chicken macrophages.
The histologic liver lesions in chicks in this study were dose related and similar to those in horses and rats given fumonisin. Rickets has been seen in poultry consuming rations with Fusarium and Fusarium moniliforme, but the causative toxin and the pathologic mechanism of its induction have not been determined.
In the present trial, diarrhea in fumonisintreated chicks may have led to intestinal malabsorption or maldigestion of vitamin D, calcium or phosphorus,resulting in secondary rickets. No previous reports had associated diarrhea with fumonisin toxicity,
therefore no intestinal tissues were collected for histologic evaluation. Thymic cortical atrophy is frequently seen in broiler chicks undergoing disease stress.
No immunologic assessment of the impact of this thymic lesion was attempted in this pilot study, but Fusarium equiseti2 and Fusarium moniliforme suppress humoral immunity in chickens. Fumonisin B1 also induces morphologic and functional alterations in chicken macrophages.
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