Bioassays. The cytotoxic activity assay was performed using the
colorimetric method of Skehan and co-workers.14 The human oral
epidermal carcinoma (KB), human breast adenocarcinoma (MCF7),
and human small cell lung (NCI-H187) cell lines were used. Antiplasmodial
activity was evaluated against Plasmodium falciparum (K1 multidrug-
resistant strain) according to a standard protocol