The result of our study are in agreement with other studies (King
et al., 1991; Ren et al., 2004) showing that the local application
of hyaluronic acid could promote cell proliferation and migration
in the healing tissue and alternatively, the role of hyaluronic acid
in water homeostasis could favor tissue hydration, which has a
well-known beneficial effect on healing. Besides, result of a study
indicated that it is conceivable that hyaluronan administration
to periodontal site could achieve comparable beneficial effects
in periodontal healing and surgery (Moseley et al., 2002). These
are, however, partly in contrast with a study where the authors
observed that in a sheep model of chronic sinusitis, a dissolvable
hyaluronic acid-based pack did not have any significant effect on
mucosal healing (Rajspaksa et al., 2005).